| FRONTIER IN MEDICINE |
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| Year : 2012 | Volume
: 14
| Issue : 1 | Page : 46-48 |
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Neural stem cells and post traumatic epilepsy: The importance of seizure control
KI Mathai1, S Ranjan2, S Das3, A Chagla4
1 Senior Advisor, Neurosurgery, INHS Asvini, Colaba, Mumbai 400 005, India
2 Senior Advisor, Medical Oncology, INHS Asvini, Colaba, Mumbai 400 005, India
3 Senior Advisor, Paediatric & Haematology, INHS Asvini, Colaba, Mumbai 400 005, India
4 Professor, Dept of Neurosurgery, KEM Hospital, Mumbai, India
Correspondence Address:
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0975-3605.203231
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Post traumatic seizures induce structural and neurochemical changes in the Neural Stem cell (NSC) niches. The NSC niche shows a classic biphasic response to seizures. In the early weeks after a post traumatic seizure, there is an increase in neurogenesis. However, the integration of these new neurons into existing circuitry is defective leading on to epileptogenic circuits. As seizures continue, there is a decrease in neural proliferation, with consequences on cognition and mood. In this article, we explore the aetiopathogenesis of hippocampal epileptic circuitry and discuss conceptual and evolving therapeutic options.
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