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Year : 2013  |  Volume : 15  |  Issue : 1  |  Page : 14-18

Clinical and hematological features of dengue in children presenting at a zonal hospital in a dengue-naive area

1 Classified Specialist (Pediatrics), INHS Kalyani, Gandhigram Post, Visakhapatnam - 530 005, India
2 Classified Specialist (Pathology), INHS Kalyani, Gandhigram Post, Visakhapatnam - 530 005, India
3 Medical Officer (Vikramaditya Cell), INHS Kalyani, Gandhigram Post, Visakhapatnam - 530 005, India
4 Senior Advisor (Pediatrics and Neonatology), INHS Kalyani, Gandhigram Post, Visakhapatnam - 530 005, India

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0975-3605.203266

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Background: Dengue infection is endemic in most regions of India and is a major cause of morbidity and mortality. There is paucity of data from the Armed Forces. This report on 52 children is from a Zonal Hospital in a dengue-naïve area. Methods: A prospective, observational study of clinical features and laboratory parameters in children up to 15 years with dengue infection confirmed by ELISA for NS1 antigen. Results: Mean age was 9.9 years, male to female ratio 1.08:1. All 52 had Dengue Fever with no hemorrhagic manifestations and all recovered. Leading symptoms were nausea (53.85%), myalgia (51.92%) and vomiting (50%). Significant laboratory findings included leucopenia (<6000/cumm) in 90.38%, thrombocytopenia (<l,00,000/cumm) in 23.08%; elevated aspartateaminotransferase in 45.45% and raised alanineaminotransferase in 36.36%. All abnormalities resolved spontaneously. Conclusion: Lack of serious manifestations of dengue, nausea as the leading symptom, marked leucopenia and relatively less thrombocytopenia and elevation of liver enzymes, are aspects of this study different from reports of other published studies and therefore need further research. Pooling and analyzing data from all Armed Forces hospitals and extension of advanced investigation facilities to all hospitals would provide fresh insights to aid in better management of dengue infections in children.

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