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CASE REPORT
Year : 2016  |  Volume : 18  |  Issue : 1  |  Page : 54-59

Acute skin failure due to toxic epidermal necrolysis - Allopurinol induced


1 Resident, Dept of Dermatology, INHS Asvini, Colaba - 400005, Mumbai, India
2 Consultant, Dept of Dermatology, INHS Asvini, Colaba - 400005, Mumbai, India
3 Prof & HOD (Derm &VD), Dept of Dermatology, INHS Asvini, Colaba - 400005, Mumbai, India
4 Resident (Derm & VD), Dept of Dermatology, INHS Asvini, Colaba - 400005, Mumbai, India

Correspondence Address:
B S Gill
Resident, Dept of Dermatology, INHS Asvini, Colaba - 400005, Mumbai
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-3605.202983

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Toxic epidermal necrolysis (TEN) is a life-threatening, typically drug-induced, mucocutaneous disease. TEN has a high mortality rate, making early diagnosis and treatment of paramount importance. New but experimental diagnostic tools that measure serum granulysin and high-mobility group protein B1 (HMGB1) offer the potential to differentiate early TEN from other, less serious drug reactions, but these tests have not been validated and are not readily available. The mainstay of treatment for TEN involves discontinuation of the offending drug, specialized care in an intensive care unit or burn center, and supportive therapy. The effectiveness of systemic steroids, intravenous immunoglobulins, plasmapheresis, cyclosporine, biologies, and other agents is uncertain.


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