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ORIGINAL ARTICLE
Year : 2022  |  Volume : 24  |  Issue : 2  |  Page : 138-141

Cytokine response to antitubercular therapy in patients with human immunodeficiency virus and tuberculosis coinfection with respect to CD4 count and viral load − A pilot study


1 Military Hospital, Jabalpur, Madhya Pradesh, India
2 DY Patil School of Medicine, Nerul, Navi Mumbai, India
3 Base Hospital, Barrakpore, West Bengal, India
4 Department of Internal Medicine, Armed Forces Medical College, Pune, Maharashtra, India

Correspondence Address:
Brig (Prof) Nagesh Venkata Ivaturi
Military Hospital, Jabalpur, Madhya Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jmms.jmms_153_21

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Introduction and Background: Monitoring of efficacy of antitubercular treatment (ATT) in patients with human immunodeficiency virus (HIV) and tuberculosis (TB) coinfection is more often based on clinical judgment. Having an objective biomarker monitor, the treatment response to ATT is urgently required in HIV-TB coinfection. Methodology: Fifty patients of diagnosed HIV infection with TB as opportunistic infection were enrolled. Baseline CD4 and HIV viral load were done. Serum cytokine levels of IFN γ, IL-10, IL-2, and interferon gamma-inducible protein-10 (IP-10) were assessed at baseline and after 2 months of initiation of ATT. Results: Out of fifty patients, 43 (86%) were male and 7 (14%) were female. The mean age of the patients was 39 years. The median CD4 count was 342 cells/uL, and the mean plasma HIV viral load was 3,05,093 copies/ml. Sputum for AFB was positive in 15 (30%) patients. The levels of interferon-gamma (INF γ), interleukin (IL)-4, and IL-10 have shown a statistically significant decline over 2 months [Table 1] with a P = 0.005, <0.001, and 0.023, respectively. There was a significant correlation between IP-10 and CD4 count in male patients as assessed by Pearson correlation coefficient (P = 0.048). Conclusion: The levels of INF γ, IL-4, and IL-10 have shown a statistically significant decline over 2 months [Table 1] with a P = 0.005, <0.001, and 0.023, respectively. There was a significant correlation between IP-10 and CD4 count in male patients.


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