• Users Online: 328
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2022  |  Volume : 24  |  Issue : 2  |  Page : 154-158

COVID-19 breakthrough infections amongst ChAdOx1 nCoV-19 (Covishield) vaccinated health-care workers and its clinical manifestations: A prospective observational study


1 Department of Medicine, INS India, New Delhi, India
2 Department of Gynaecology, NH Powai, Mumbai, Maharashtra, India
3 Department of Medicine, INHS Kalyani, Visakhapatnam, Andhra Pradesh, India

Correspondence Address:
Surg Lt Cdr (Dr) Vaidehi Thakur
Department of Gynaecology, NH Powai, Mumbai, Maharashtra
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jmms.jmms_26_22

Rights and Permissions

Introduction: Second wave of the COVID -19 pandemic had a significant impact on India with large number of populations getting affected by it. Pan -India COVID -19 vaccination was started on 16 January 2021. All the hospital Health Care Workers (HCWs) started receiving Covishield vaccine. By March 2021, all the HCWs received 02 dosages of the vaccine. It was the time when the second wave of COVID-19 started in India. This study was conducted to investigate the occurrence and severity of breakthrough COVID -19 infection (BCI) amongst fully vaccinated HCWs. Materials and Methods: This prospective observational study was conducted at a single multispecialty COVID-19 dedicated hospital on fully vaccinated HCWs who developed BCI. A total of 981 HCWs were enrolled and observed them for six months from March -September 2021 for occurrence of BCI. The outcome measures included percentage of fully vaccinated HCWs developing BCI. The BCI according to various demographic variables was studied. Clinical profile, duration between last dose of vaccine and BCI and requirement of mechanical ventilation were analysed. Results: Out of 981 fully vaccinated HCWs, 97 developed BCI. Amongst one -fifth of them were asymptomatic. Fever and cough were the prominent symptoms. Two HCWs developed COVID -19 pneumonia. None required oxygen supplementation or mechanical ventilation. There was no death observed amongst these COVID -19 infected HCWs. Discussion: BCI occurred in 9.88% fully vaccinated HCWs. They were primarily minor and did not lead to severe disease. Overall, Covishield prevented severe infection in HCWs, leading to decreased ICU admission and deaths.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed385    
    Printed31    
    Emailed0    
    PDF Downloaded25    
    Comments [Add]    

Recommend this journal