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Central diabetes insipidus: A case series and literature review

1 Department of Endocrinology, INHS ASVINI, Mumbai, Maharashtra, India
2 Department of Pathology, INHS ASVINI, Mumbai, Maharashtra, India
3 Department of Radiology, INHS ASVINI, Mumbai, Maharashtra, India
4 Department of Neurosurgery, INHS ASVINI, Mumbai, Maharashtra, India

Correspondence Address:
Vikram Singh Shekhawat,
Department of Endocrinology, INHS Asvini, Mumbai, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jmms.jmms_124_21

Central diabetes insipidus (CDI) is a rare disorder of water homeostasis characterized by the excretion of a large volume of hypotonic urine resulting from deficient secretion of arginine vasopressin. It is the most common form of diabetes insipidus and manifests when more than 90% of the vasopresinergic magnocellular neurons have been destroyed. The correct diagnosis is always a challenge as it is not always possible to differentiate the different etiologies of CDI based on clinical, hormonal, and radiological examination alone. Histopathology may have to be resorted to at times to provide a definitive diagnosis. In this case series, we describe five patients of CDI with varied etiologies and briefly discuss the evaluation and management of patients with CDI.

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